Top Health Startups in 2025
The U.S. healthcare innovation landscape is undergoing a dynamic transformation, propelled by strong funding momentum and rapid technological advancements. In 2024–2025, startups are playing a pivotal role in reshaping care delivery, with a marked focus on AI-driven platforms, telehealth expansion, chronic disease management, and digital therapeutics. Venture capital investment in digital health remains resilient, with companies leveraging AI to personalize care, reduce costs, and improve outcomes at scale.
At the same time, a new wave of startups is gaining traction in 2024–2025, focusing on niche but critical areas such as obesity treatment, women’s health, value-based care models, and behavioral health tech. These companies are not only innovating on the technology front but are also navigating complex regulatory and reimbursement landscapes to bring scalable solutions to market. As healthcare shifts toward a more connected, patient-centric model, these emerging startups are well-positioned to become the next leaders in the sector.
Healthcare Technology Companies to Know
PathAI is a leading health tech startup using artificial intelligence to improve pathology diagnostics, especially in detecting cancer. Its tools enhance diagnostic accuracy, speed, and consistency by analyzing digital pathology slides with deep learning. Their platform, AISight®, integrates AI models like TumorDetect™ to identify cancerous regions in tissue samples quickly. PathAI also develops biomarker-scoring tools for HER2, PD-L1, and other key cancer indicators.
Aidoc is an AI-powered platform that assists radiologists in detecting urgent conditions like brain bleeds, pulmonary embolisms, and strokes. It analyzes medical images in real-time to prioritize critical cases and speed up diagnosis. Aidoc integrates seamlessly into existing hospital systems for smooth clinical workflows. The platform supports improved patient outcomes by reducing time to treatment. Trusted globally, Aidoc enhances radiology efficiency and clinical decision-making.
Kheiron Medical, now part of DeepHealth, is transforming breast cancer detection through its AI platform, Mia® (Mammography Intelligent Assessment). Mia uses deep learning to support radiologists by acting as an independent or concurrent reader, improving the accuracy and efficiency of mammogram screenings. Clinical studies have shown that Mia can detect up to 13% more cancers and reduce radiologist workload by around 30%.
MindMaze is a leader in digital neurotherapeutics, using AI, virtual reality, and motion tracking to treat neurological conditions like stroke, Parkinson’s, and traumatic brain injury. Their FDA-cleared and CE-marked platforms, such as MindMotion GO and MindPod, deliver engaging, protocol-based rehab therapies.
Insitro is a biotechnology company that uses machine learning and large-scale biological data to revolutionize drug discovery. By combining AI with human genetics, cellular models, and clinical data, Insitro builds predictive models to identify new therapeutic targets.
Superpower is an AI-powered health app founded in 2023. It integrates lab tests, medical records, and wearable data in one place. Our platform generates real-time, personalized health plans for every user. We focus on prevention, optimization, and long-term wellbeing. Superpower turns your health data into daily, actionable insights.
Viome (Washington) is a healthtech startup that uses metatranscriptomics and AI to analyze RNA from saliva, stool, and blood. This enables personalized nutrition, supplement recommendations, and early disease detection, including oral and throat cancers. Its at-home test kits are easy to use and deliver clinical-grade insights. Viome is backed by top investors like Marc Benioff (Salesforce) and Khosla Ventures. The platform merges cutting-edge science with a consumer-friendly digital experience for proactive health management.
It is a clinical AI-powered primary care platform founded in 2016. It offers a smart symptom checker that compares user inputs to millions of de-identified case records, guiding users to appropriate care and connecting them with licensed clinicians via chat or video. The company’s AI Physician Mode, integrated with major health systems like Mayo Clinic, Cedars-Sinai, Hackensack Meridian, and Hartford HealthCare, automates patient intake and synthesizes EMR histories into “perfect charts” for clinicians—improving workflow efficiency and diagnostic accuracy.
Sword Health (U.S. + Portugal)
Sword Health is a digital-first musculoskeletal (MSK) care company that blends wearable motion sensors, AI, and human-guided therapy to deliver in-home physical rehabilitation. Its Digital Therapist platform pairs Doctor of Physical Therapy (DPT) guidance with real-time AI-enabled feedback to personalize and refine exercise programs. Clinical data supports impressive outcomes—67% of users report being pain-free, 64% see reduced depression, and surgery intentions drop by up to 70%; often outperforming traditional therapy and generating substantial cost savings for employers and health plans.
Spikewell (Massachusetts)
Spikewell’s core offerings include SpikeSupport.ai, an AI-powered IT support platform that automates issue triage and resolution with over 98% accuracy, and Vitalytics.ai, which delivers real-time, data-driven clinical insights by aggregating and contextualizing patient data from multiple systems. Another standout innovation, BlueDot, provides Bluetooth-based indoor intelligence for hospital navigation and asset tracking, addressing one of healthcare’s most persistent logistical challenges.
In early 2025, Abridge raised $250 million in funding to accelerate its growth across approximately 100 major U.S. health systems, including UPMC, Emory Healthcare, and Yale New Haven Health. Its platform supports multiple specialties and care settings, using large language models (LLMs) specifically tuned for medical language. By automating progress notes, after-visit summaries, and documentation workflows, Abridge is rapidly emerging as the go-to co-pilot for modern healthcare providers seeking scalable, compliant, and ambient clinical documentation solutions.
Eko Health, based in Oakland, California, is a medtech company that develops AI-augmented digital stethoscopes and diagnostic software to improve the detection and management of cardiovascular and pulmonary diseases. Its flagship device, the CORE 500™, is the first digital stethoscope to combine a high-fidelity stethoscope, a 3-lead ECG, and FDA-cleared AI algorithms—all in one handheld tool. The CORE 500™ delivers up to 40x sound amplification, TrueSound™ active noise cancellation, and a full-color display, helping clinicians identify abnormal heart sounds like murmurs, AFib, and low ejection fraction with greater speed and accuracy than traditional auscultation tools.
Manas AI is a pioneering drug discovery startup co-founded in January 2025 by Reid Hoffman (LinkedIn co-founder and Microsoft board member) and Dr. Siddhartha Mukherjee (Pulitzer Prize-winning oncologist and author of The Emperor of All Maladies). The company leverages generative AI, computational chemistry, and proprietary biology to dramatically accelerate the identification and development of novel cancer therapies. Initially targeting aggressive forms such as triple-negative breast cancer, prostate cancer, and lymphoma, Manas AI develops bespoke chemical libraries and uses Microsoft Azure's cloud infrastructure to achieve docking speeds up to 100× faster than traditional methods.
Since its launch, Doctronic has conducted over 10 million free consultations, engaging around 50,000 users each week. In April–May 2025, it closed a $5?million seed round led by Union Square Ventures, with backing from Tusk Ventures and HF0, supporting continued product refinement, hiring, and expansion of its nationwide physician network. The platform plans to integrate wearables, lab services, and automated prescriptions—reinforcing its mission to democratize baseline primary care across the U.S., bypassing traditional insurance barriers and long wait times.
Kinsa is a San Francisco-based health technology company that combines smart thermometers with an AI-powered public health platform to track and predict illness spread in real time. Its FDA-cleared devices collect anonymized fever data from millions of households, enabling early detection of outbreaks and forecasting flu and respiratory illness trends weeks ahead of traditional systems. The platform supports families with personalized health guidance and helps hospitals, schools, and retailers prepare for surges in illness.